منابع مشابه
Molecular and Structural Basis for Redox Regulation of β-Actin
0022-2836/$ see front matter © 2007 E Anessential consequence of growth factor-mediated signal transduction is the generation of intracellular H2O2. It operates as a second messenger in the control of actin microfilament dynamics, causing rapid and dramatic changes in the morphology andmotile activity of stimulated cells. Little is understood about the molecular mechanisms causing these changes...
متن کاملMolecular chaperones and proteostasis regulation during redox imbalance☆
Free radicals originate from both exogenous environmental sources and as by-products of the respiratory chain and cellular oxygen metabolism. Sustained accumulation of free radicals, beyond a physiological level, induces oxidative stress that is harmful for the cellular homeodynamics as it promotes the oxidative damage and stochastic modification of all cellular biomolecules including proteins....
متن کاملRedox regulation
he protein that does everything, 14–3-3, has now been shown to direct traffic. Ita O'Kelly, Steve Goldstein, and colleagues (Yale University, New Haven, CT) find that 14–3-3 can displace -COP from various proteins, thus freeing them from retention in the ER and leading to surface expression. Goldstein set out to find proteins interacting with the COOH terminus of a K ϩ leak channel, KCNK3, and...
متن کاملRedox-dependent transcriptional regulation.
Reactive oxygen species contribute to the pathogenesis of a number of disparate disorders including tissue inflammation, heart failure, hypertension, and atherosclerosis. In response to oxidative stress, cells activate expression of a number of genes, including those required for the detoxification of reactive molecules as well as for the repair and maintenance of cellular homeostasis. In many ...
متن کاملRedox regulation in cancer
Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS deregulate the redox homeostasis and promote tumor formation by initiating an aberrant induction of signaling networks that cause tumorigenesis. Ultraviolet (UV) exposures, gamma-radiation and other environmental carcinogen...
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ژورنال
عنوان ژورنال: BMC Molecular Biology
سال: 2009
ISSN: 1471-2199
DOI: 10.1186/1471-2199-10-86